Microbiome Production Technician

Company: University of Chicago
Location: Chicago
Posted on: April 1, 2026

Job Description:

Department BSD DFI - cGMP About the Department The Duchossois Family Institute (DFI) at the University of Chicago is at the forefront of microbiome research, leveraging advanced technologies in newly established, state-of-the-art facilities to accelerate research and introduce novel interventions that optimize microbiome-mediated host defenses, with the goal of enhancing human health. By developing new knowledge about the interactions between the human body and the microbiome, the DFI is breaking new ground, pioneering therapies that harness the microbiome – revolutionizing the prevention and treatment of a wide range of diseases. This at-will position is wholly or partially funded by contractual grant funding which is renewed under provisions set by the grantor of the contract. Employment will be contingent upon the continued receipt of these grant funds and satisfactory job performance. Job Summary We are seeking a Microbiome Production Technician for our current Good Manufacturing Practices (cGMP) facility. This facility represents a first-of-its-kind, state-of-the-art, adaptable microbiome biomanufacturing center strategically embedded at the interface of a world-class microbiome sciences research team and a patient-centric medical center. Its mission is to translate bench innovations into clinical investigations. Our objective is to embed a focused biotech product development capability within an advanced academic research environment, with the goal of driving patient value by addressing unmet medical needs in record time. The DFI’s goal is to optimize or augment microbiome functions that enhance disease resistance. This role supports the production and quality control testing of drug substance and drug products that are manufactured at the DFI cGMP Facility. Additionally, this position also contributes to research efforts, aiding in the advancement of Live Biotherapeutic Products from development all the way through production. Responsibilities Partner with the bioprocessing team to define and characterize live biotherapeutic products (LBPs) for scalable production within a cGMP biomanufacturing facility. Assist in optimizing media formulation and fermentation conditions for various anaerobic bacteria. Help refine fermentation parameters to enhance LBP yield and viability. Help identify harvest conditions that maximize viability and stability of LBPs. Perform rigorous Quality Control (QC) testing, including CFU counts, USP compendial tests, for drug substance and drug products. Conduct biomanufacturing operations – including environmental monitoring, media production, fermentation, tangential filtration, lyophilization, encapsulation, and facility cleaning - in a cGMP cleanroom environment. Operate and maintain specialized laboratory equipment under guidance from senior Production associates such as Anaerobic chambers, Biological safety cabinets, Bioreactors/fermenters, Tangential flow filtration systems, Lyophilization system, MALDI Biotyper, spectrophotometers, and pH meters. Perform routine cleaning, proper setup, care, and preventive maintenance of all laboratory equipment. Perform hands-on biomanufacturing operations for fermentation, purification, lyophilization, encapsulation and cryopreservation of LBPs under guidance from senior Production associates. Maintain the highest standards of laboratory workplace safety, quality, and cGMP compliance. Complete all training requirements for applicable Standard Operating Procedures (SOPs). Meticulously record executed work in batch records, logs, and forms as outlined per established SOPs. Support QA, QC, and regulatory documentation and audit requirements. Follow all verbal and written instructions and procedures for processes and equipment. Identify and report non-conforming events promptly. Consistently comply with SOPs and regulatory guidelines. Conducts new tests and researches on new technologies for implementation in the laboratory. Solves routine or standard problems relating to the collection and management of patient results and data. Has general awareness of safety, quality control, and quality assurance procedures. Maintains quality and safety control measures for the laboratory. Performs other related work as needed. Minimum Qualifications Education: Minimum requirements include a college or university degree in related field. Work Experience: Minimum requirements include knowledge and skills developed through Certifications: Preferred Qualifications Education: B.S. degree in Biological, Chemical, or Bioprocess Engineering. Degree in Microbiology, Biomedical Engineering or a closely related life sciences field also considered. Experience: Hands-on experience in biomanufacturing is desired. Experience in operating general laboratory equipment: balances, vortex, pH meters, centrifuge and microscope. Experience in basic laboratory techniques: pipetting, aseptic technique, serial dilutions, plate streaking, weighing solids, and making buffers and standard solutions. Experience working with aerobic and anaerobic microbes, including cultivation and handling techniques under aseptic conditions. Preferred Competencies Strong analytical and problem-solving skills for bioprocess optimization. Proven ability to work cooperatively within interdisciplinary team environments. Teamwork, effective communication, and adaptability in regulated biomanufacturing environment. Consistent, dependable performance and strong work ethic; regular attendance and reliability. Ability to work for extended periods in cGMP/cleanroom environments while maintaining attention to detail and safety protocols. Excellent written and oral communication skills, ensuring clear and professional documentation and interpersonal interaction. Experience in performing CFU (colony-forming unit) counts and USP compendial testing to ensure product identity, potency, purity, and safety. Demonstrates proficiency in essential laboratory techniques, equipment operation, aseptic processing, and accurate sample handling. Demonstrates proficiency in Good Documentation Practices (GDP), accurate record keeping, and maintaining detailed batch records, logs, and forms to support regulatory compliance and product traceability. Upholds rigorous standards of cleanliness and organization in the laboratory and cleanroom environments. Working Conditions Office environment. Laboratory environment. Application Documents Resume (required) Cover Letter (preferred) When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application. Job Family Research Role Impact Individual Contributor Scheduled Weekly Hours 40 Drug Test Required No Health Screen Required Yes Motor Vehicle Record Inquiry Required No Pay Rate Type Hourly ? FLSA Status Non-Exempt ? Pay Range $24.04 - $33.65 The included pay rate or range represents the University’s good faith estimate of the possible compensation offer for this role at the time of posting. Benefits Eligible Yes The University of Chicago offers a wide range of benefits programs and resources for eligible employees, including health, retirement, and paid time off. Information about the benefit offerings can be found in the Benefits Guidebook . Posting Statement The University of Chicago is an equal opportunity employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender, gender identity, or expression, national or ethnic origin, shared ancestry, age, status as an individual with a disability, military or veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination. Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5800 or submit a request via Applicant Inquiry Form. All offers of employment are contingent upon a background check that includes a review of conviction history. A conviction does not automatically preclude University employment. Rather, the University considers conviction information on a case-by-case basis and assesses the nature of the offense, the circumstances surrounding it, the proximity in time of the conviction, and its relevance to the position. The University of Chicago's Annual Security & Fire Safety Report (Report) provides information about University offices and programs that provide safety support, crime and fire statistics, emergency response and communications plans, and other policies and information. The Report can be accessed online at: http://securityreport.uchicago.edu . Paper copies of the Report are available, upon request, from the University of Chicago Police Department, 850 E. 61st Street, Chicago, IL 60637.

Keywords: University of Chicago, Mount Prospect , Microbiome Production Technician, Science, Research & Development , Chicago, Illinois