VP of Product - Oncology – Somatic Tissue
Company: Tempus AI
Location: Chicago
Posted on: April 2, 2026
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Job Description:
Passionate about precision medicine and advancing the healthcare
industry? Recent advancements in underlying technology have finally
made it possible for AI to impact clinical care in a meaningful
way. Tempus' proprietary platform connects an entire ecosystem of
real-world evidence to deliver real-time, actionable insights to
physicians, providing critical information about the right
treatments for the right patients, at the right time. The Vice
President of Product, Oncology – Somatic Tissue Diagnostics, is a
visionary executive responsible for setting the strategic
direction, execution, and innovation of the company’s somatic
tissue diagnostic portfolio. This role oversees the entire product
lifecycle—from ideation and R&D coordination to commercial
launch, promotion, and P&L management—ensuring all initiatives
address current and emerging clinical oncology needs and align with
business objectives. You will lead the development of cutting-edge
diagnostic technologies, including advanced NGS-based assays and
multiomic platforms, to deliver precise, actionable insights for
cancer care and drive improved patient outcomes. The ideal
candidate is an entrepreneurial, expert-level leader with hands-on
experience in product management of somatic tissue diagnostics
(LDTs or IVDs) and a proven ability to implement phase-gated
Product Development Processes (PDP) in oncology. Responsibilities:
Strategic Oncology Portfolio Roadmap: Develop and manage a
comprehensive product roadmap for the oncology somatic tissue
diagnostics portfolio, integrating customer feedback, technology
advancements, and clinical oncology trends to address unmet needs
in cancer diagnostics. Market & Competitive Analysis: Lead in-depth
market research and competitive analyses against industry leaders
in oncology diagnostics (e.g., Foundation Medicine, Guardant
Health, Caris Life Sciences) to identify portfolio gaps, emerging
opportunities, and potential differentiators. Product Lifecycle
Management: Oversee upstream Product Managers in end-to-end
lifecycle management for somatic tissue molecular testing services,
ensuring successful launches and continuous enhancements of assays
and platforms tailored for oncology applications. Commercial
Strategy Execution: Drive product positioning, messaging, and
go-to-market (GTM) strategies for oncology diagnostics by guiding
downstream Marketing Managers and collaborating closely with sales,
market access, and medical affairs teams to maximize adoption and
clinical impact. Portfolio P&L Management: Maintain full
accountability for the oncology product portfolio P&L, focusing
on revenue growth, resource allocation, and measurable business
outcomes. Stakeholder Engagement: Build strong relationships with
key opinion leaders, oncologists, pathologists, and patient
advocacy groups to inform product strategy and support clinical
adoption. Regulatory & Compliance Leadership: Ensure product
development and commercialization meet all regulatory requirements
for oncology diagnostics, including FDA, CLIA, CAP, and
international standards. Required Skills: Strategic Market Access &
Value Storytelling: Ability to develop and communicate a compelling
value proposition that demonstrates the clinical and economic
benefits of oncology diagnostics to payers, providers, and health
systems. Expertise in navigating complex reimbursement landscapes
and designing creative pricing or risk-sharing models for cancer
testing. Patient-Centric Advocacy & Empathy: Specialized capability
to integrate the patient journey and voice into product design and
commercial strategy, including engagement with oncology patient
advocacy groups to address barriers such as access, cost, and
equity. Data-Driven Predictive Analytics: Proficiency in leveraging
advanced data science and AI models to identify clinical gaps,
optimize test utilization, and forecast adoption obstacles in
oncology diagnostics. Cross-Functional Matrix Leadership: Ability
to influence and lead multidisciplinary teams—including R&D,
Medical Affairs, Regulatory, and Sales—without direct authority,
harmonizing these groups to ensure products remain clinically
relevant and commercially successful. Agile & Adaptive
Decision-Making: High-level ability to make critical, data-informed
decisions under pressure in the rapidly evolving oncology
diagnostics landscape, including strategic agility to pivot the
product roadmap in response to new clinical discoveries or
regulatory changes. Regulatory & Quality Expertise: Strong
understanding of regulatory pathways and quality standards for
oncology diagnostics, including FDA submissions, CLIA validation,
and CAP accreditation. Required Education & Experience: Required
Education: Bachelor’s degree in Biology, Genetics, Oncology, or a
related scientific field. Preferred Education: Advanced degree such
as an MBA, PhD, or MD is highly preferred, bridging the gap between
complex science, clinical oncology, and business strategy.
Specialized Knowledge: Deep understanding of oncology, including
somatic mutation biology, cancer genomics, clinical workflows, and
the evolving landscape of tissue diagnostics. Commercial Knowledge:
Extensive knowledge of market demands, technology trends, and the
regulatory environment for oncology molecular diagnostics.
Preferred Experience: Leadership Tenure: Minimum of 10 years of
progressive leadership experience in product management,
specifically within oncology diagnostics, molecular pathology, or
genetics-based healthcare. Portfolio Growth: Proven track record of
developing complex portfolio plans and leading successful
commercial launches of oncology diagnostic tests at scale in a
competitive market. Oncology Expertise: Significant experience
navigating the unique challenges of the oncology diagnostics
market, including specialized billing practices, regulatory
pathways, and patient-centric programs. This role works with
Personal Health Information (PHI) on a regular basis both in paper
and electronic form, and therefore training relating to HIPAA/PHI
privacy, General Policies and Procedure Compliance training and
security training will be required upon hire. Salary Range:
250,000- 350,000 USD The expected salary range above is applicable
if the role is performed from Illinois and may vary for other
locations (California, Colorado, New York). Actual salary may vary
based on qualifications and experience. Tempus offers a full range
of benefits, which may include incentive compensation, restricted
stock units, medical and other benefits depending on the position.
We are an equal opportunity employer. We do not discriminate on the
basis of race, religion, color, national origin, gender, sexual
orientation, age, marital status, veteran status, or disability
status.
Keywords: Tempus AI, Mount Prospect , VP of Product - Oncology – Somatic Tissue, Healthcare , Chicago, Illinois
